Comprehensive motion‐compensated highly accelerated 4D flow MRI with ferumoxytol enhancement for pediatric congenital heart disease

作者：Joseph Y. Cheng, Kate Hanneman, Tao Zhang, Marcus T. Alley, Peng Lai, Jonathan I. Tamir, Martin Uecker, John M. Pauly, Michael Lustig, Shreyas Vasanawala · 发表于：Journal of Magnetic Resonance Imaging · 年份：2015 · DOI：10.1002/jmri.25106 · 被引用次数：123 · 研究领域：Advanced MRI Techniques and Applications、Congenital Heart Disease Studies、Cardiac Imaging and Diagnostics

PURPOSE: To develop and evaluate motion-compensation and compressed-sensing techniques in 4D flow MRI for anatomical assessment in a comprehensive ferumoxytol-enhanced congenital heart disease (CHD) exam. MATERIALS AND METHODS: A Cartesian 4D flow sequence was developed to enable intrinsic navigation and two variable-density sampling schemes: VDPoisson and VDRad. Four compressed-sensing methods were developed: A) VDPoisson scan reconstructed using spatial wavelets; B) added temporal total variation to A; C) VDRad scan using the same reconstruction as in B; and D) added motion compensation to C. With Institutional Review Board (IRB) approval and Health Insurance Portability and Accountability Act (HIPAA) compliance, 23 consecutive patients (eight females, mean 6.3 years) referred for ferumoxytol-enhanced CHD 3T MRI were recruited. Images were acquired and reconstructed using methods A-D. Two cardiovascular radiologists independently scored the images on a 5-point scale. These readers performed a paired wall motion and functional assessment between method D and 2D balanced steady-state free precession (bSSFP) CINE for 16 cases. RESULTS: Method D had higher diagnostic image quality for most anatomical features (mean 3.8-4.8) compared to A (2.0-3.6), B (2.2-3.7), and C (2.9-3.9) with P < 0.05 with good interobserver agreement (κ ≥ 0.49). Method D had similar or better assessment of myocardial borders and cardiac motion compared to 2D bSSFP (P < 0.05, κ ≥ 0.77). All methods had go...