PREPARATION AND EVALUATION OF SOLID DISPERSION OF ASIATIC ACID WITH PVPK30

作者：Songbai Liao, Qiang Ma, Gaihong An, Na Zhang, Chuanxiang Xu, Bo Cui, Xiaojun She, Ron Fan, Yongcong Shao, Xuewei Chen · 年份：2013 · 被引用次数：8 · 研究领域：Medicinal Plants and Neuroprotection、Advanced Chemical Sensor Technologies、GABA and Rice Research

Solid dispersions of Asiatic acid with a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) was prepared by the solvent evaporation method. The effect of Asiatic acid: PVPk30 feed ratio by weight on the aqueous solubility was investigated, the aqueous solubility of Asiatic acid reached 2043μg/ml when the weight ratio of Asiatic acid to PVPk30 was 1:5. The aqueous solubility of Asiatic acid was increased by 20-fold in Asiatic acid/ PVPk30 solid dispersions. The Asiatic acid/ PVPk30 solid dispersions system was characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM). The FTIR spectra of Asiatic acid/ PVPk30 solid dispersions showed that the presence of strong interactions between Asiatic acid and PVPk30. The SEM and DSC spectrum of Asiatic acid/ PVPk30 solid dispersions indicated Asiatic acid existed in amorphous state, this could be explained the fact that the aqueous solubility of Asiatic acid was increased.