Method Development and Validation of Baclofen Mouth Dissolving Tablets by UV Spectroscopy

作者：Tabinda Islam, Samina Ferdous, Preeti Jain, Hasan Mahmud Reza · 年份：2013 · 被引用次数：5 · 研究领域：Plant-based Medicinal Research、Microfluidic and Capillary Electrophoresis Applications、Botulinum Toxin and Related Neurological Disorders

The UV spectroscopic method of analysis is widely used for routine analytical procedure for determination of chemical compounds. The aim of this investigation was to develop and validate a simple, easy and sensitive UV spectrophotometric method for the analytical evaluation of the formulated Baclofen 5 mg experimental tablet. Baclofen shows maximum absorbance at a wavelength of 220 nm, which has been used in this study. The method provides a linear response from a quantitation range of 4µg/ml to 28 µg/ml in 0.1N HCl. The method gave satisfactory results in terms of repeatability (RSD 0.09%). The method was validated and proved to be robust and rugged. Our results demonstrate that UV spectrophometric method can be used for rapid determination of Baclofen in bulk and experimental formulation.