Minimum Information about a Biosynthetic Gene cluster

作者：Marnix H. Medema, Renzo Kottmann, Pelin Yilmaz, Matthew Cummings, John B. Biggins, Kai Blin, Irene de Bruijn, Yit‐Heng Chooi, Jan Claesen, Roger Coates, Pablo Cruz‐Morales, Srikanth Duddela, Stephanie Düsterhus, Daniel J Edwards, David Peter Fewer, Neha Garg, Christoph Geiger, Juan Pablo Gomez‐Escribano, Anja Greule, Michalis Hadjithomas, Anthony S. Haines, Eric J. N. Helfrich, Matthew L. Hillwig, Keishi Ishida, Adam C. Jones, Carla S. Jones, Katrin Jungmann, Carsten Kegler, Hyun Uk Kim, Peter Kötter, Daniel Krug, Joleen Masschelein, Alexey V. Melnik, Simone M. Mantovani, Emily A. Monroe, Marcus A. Moore, Nathan A. Moss, Hans‐Wilhelm Nützmann, Guohui Pan, Amrita Pati, Daniel Petras, F. Jerry Reen, Federico Rosconi, Zhe Rui, Zhenhua Tian, Nicholas J. Tobias, Yuta Tsunematsu, Philipp Wiemann, Elizabeth E. Wyckoff, Xiaohui Yan, Grace Yim, Fengan Yu, Yunchang Xie, Bertrand Aigle, Alexander Kristian Apel, Carl J. Balibar, Emily P. Balskus, Francisco Barona‐Gómez, Andreas Bechthold, Helge B. Bode, Rainer Borriss, Sean F. Brady, Axel A. Brakhage, Patrick Caffrey, Yi‐Qiang Cheng, Jon Clardy, Russell John Cox, René De Mot, Stefano Donadio, Mohamed S. Donia, Wilfred A. van der Donk, Pieter C. Dorrestein, Sean T. Doyle, Arnold J. M. Driessen, Monika Ehling‐Schulz, Karl-Dieter Entian, Michael Andrew Fischbach, Lena G. Gerwick, William H. Gerwick, Harald Gross, Bertolt Gust, Christian Hertweck, Monica Höfte, Susan E. Jensen, Jianhua Ju, Leonard A. Katz, Leonard Kaysser, Jonathan L. Klassen, Nancy P. Keller, Ján Kormanec, Oscar Paul Kuipers, Tomohisa Kuzuyama, Nikos C. Kyrpides, Hyung-Jin Kwon, Sylvie Lautru, Rob Lavigne, Chia Y. Lee, Linquan Bai, Xinyu Liu, Wen Liu, Andriy N. Luzhetskyy, Taifo Mahmud, Yvonne Mast, Cármen Méndez, Mikko Metsä‐Ketelä, Jason Micklefield, Douglas A. Mitchell, Bradley S Moore, Leonilde M. Moreira, Rolf Müller, Brett Anthony Neilan, Markus Nett, JENS KVIST NIELSEN, Fergal O’Gara, Hideaki Oikawa, Anne Osbourn, Marcia S. Osburne, Bohdan Ostash, Shelley M. Payne, Jean‐Luc Pernodet, Miroslav Petřı́ček, Jörn Piel, Olivier Ploux, Jos M. Raaijmakers, José A. Salas, Esther Katharina Schmitt, Barry Scott, Ryan F. Seipke, Ben Shen, David H. Sherman, Kaarina Sivonen, Michael J. Smanski, Margherita Sosio, Evi Stegmann, Roderich D. Süßmuth, Kapil Tahlan, Christopher Morton Thomas, Yi Tang, Andrew W. Truman, Muriel Viaud, Jonathan D. Walton, Christopher T. Walsh, Tilmann Weber, Gilles P. van Wezel, Barrie M. Wilkinson, Joanne M. Willey, Wolfgang Wohlleben, Gerard D. Wright, Nadine Ziemert, Changsheng Zhang, Sergey B. Zotchev, Rainer Breitling, Eriko Takano, Frank Oliver Glöckner · 发表于：Nature Chemical Biology · 年份：2015 · DOI：10.1038/nchembio.1890 · 被引用次数：927 · 研究领域：Microbial Natural Products and Biosynthesis、Microbial Metabolic Engineering and Bioproduction、Plant biochemistry and biosynthesis

A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.