The Role of Oxidative Stress in Neurodegenerative Diseases

作者：Geon Ha Kim, Jieun E. Kim, Sandy Jeong Rhie, Sujung Yoon · 发表于：Experimental Neurobiology · 年份：2015 · DOI：10.5607/en.2015.24.4.325 · 被引用次数：1358 · 研究领域：Vitamin C and Antioxidants Research、Coenzyme Q10 studies and effects、Antioxidant Activity and Oxidative Stress

Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The brain is one of organs especially vulnerable to the effects of ROS because of its high oxygen demand and its abundance of peroxidation-susceptible lipid cells. Previous studies have demonstrated that oxidative stress plays a central role in a common pathophysiology of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Antioxidant therapy has been suggested for the prevention and treatment of neurodegenerative diseases, although the results with regard to their efficacy of treating neurodegenerative disease have been inconsistent. In this review, we will discuss the role of oxidative stress in the pathophysiology of neurodegenerative diseases and in vivo measurement of an index of damage by oxidative stress. Moreover, the present knowledge on antioxidant in the treatment of neurodegenerative diseases and future directions will be outlined.