Role and regulation of RUNX2 in osteogenesis

作者：Marco Bruderer, R. Geoff Richards, Mauro Alini, Martin James Stoddart · 发表于：European Cells and Materials · 年份：2014 · DOI：10.22203/ecm.v028a19 · 被引用次数：595 · 研究领域：Bone Metabolism and Diseases、Bone health and treatments、Pneumocystis jirovecii pneumonia detection and treatment

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.