Chronic arterial and venous access in the unrestrained rat

作者：MICHAEL E. BURT, J M Arbeit, M. F. Brennan · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：1980 · DOI：10.1152/ajpheart.1980.238.4.h599 · 被引用次数：49 · 研究领域：Veterinary Pharmacology and Anesthesia、Renal function and acid-base balance、Pharmacological Effects and Assays

A system is described for chronic cannulation of the thoracic aorta and superior vena cava in the rat. This system employs a protective stainless steel coiled spring and water tight swivel and allows chronic infusion of solutions and simultaneous intermittent blood sampling for prolonged periods of time in the undisturbed unanesthetized rat. The rats (200-250 g) lost approximately 25 g in the immediate postoperative period, but then gained weight at a relatively normal rate (cannulated rats, 2.23 g/day; control rats, 2.29 g/day).