Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor

作者：Delphi Chatterjee, A. D. Roberts, K Lowell, Patrick Joseph Brennan, Ian M. Orme · 发表于：Infection and Immunity · 年份：1992 · DOI：10.1128/iai.60.3.1249-1253.1992 · 被引用次数：219 · 研究领域：Mycobacterium research and diagnosis、Immune Cell Function and Interaction、Immune Response and Inflammation

The results of this study show that lipoarabinomannans (LAM) isolated from a virulent strain and from an avirulent strain of Mycobacterium tuberculosis, which have recently been shown to differ markedly in terms of the structures of their nonreducing termini, also differ markedly in the capacity to induce the secretion of tumor necrosis factor from murine macrophages. It was found that LAM from the avirulent H37Ra strain was 100-fold more potent at inducing tumor necrosis factor secretion than LAM from the virulent Erdman strain, thus leading us to hypothesize that the structure of LAM from a given mycobacterial isolate may directly influence its ability to elicit, or avoid, cytokine-mediated mechanisms of host resistance.