Value of the prognostic nutritional index and weight loss in predicting metastasis and long-term mortality in nasopharyngeal carcinoma

作者：Xiao-Jing Du, Ling‐Long Tang, Yan‐Ping Mao, Rui Guo, Ying Sun, Ai-Hua Lin, Jun Ma · 发表于：Journal of Translational Medicine · 年份：2015 · DOI：10.1186/s12967-015-0729-0 · 被引用次数：92 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Head and Neck Cancer Studies、Nutrition and Health in Aging

BACKGROUND: To evaluate the influence of the progonistic nutritional index (PNI) and weight loss on metastasis and long-term mortality in nasopharyngeal carcinoma (NPC). METHODS: We retrospectively reviewed 694 newly diagnosed patients with non-disseminated, biopsy-proven NPC. Survival analysis was used to evaluate the predictive value of PNI and weight loss. RESULTS: Multivariate analysis demonstrated that a low pre-therapy PNI (< 55.0) was an independent predictor of poor overall survival (OS) (P = 0.012), distant metastasis-free survival (DMFS) (P = 0.011) and progression-free survival (P = 0.012). High weight loss (HWL, weight loss during treatment ≥10 %) was an independent predictor of poor OS (P = 0.001) and DMFS (P = 0.014). Advanced stage disease, female gender, chemotherapy, high white blood cell count, high serum globulin concentration and pre-therapy body-mass index were predictors of HWL. CONCLUSION: Pre-therapy PNI and weight loss have significant predictive value for metastasis and mortality in patients with NPC.