Interleukin-6 suppression reduces tumour self-seeding by circulating tumour cells in a human osteosarcoma nude mouse model

作者：Yinglong Zhang, Qiong Ma, Tao Liu, Guofeng Guan, Kailiang Zhang, Jiayan Chen, Nan Jia, Shiju Yan, Guanyin Chen, Shiluan Liu, Kuo Jiang, Yao Lu, Yanhua Wen, Haien Zhao, Yong Zhou, Qingyu Fan, Xiuchun Qiu · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.6371 · 被引用次数：33 · 研究领域：Cancer Cells and Metastasis、Sarcoma Diagnosis and Treatment、Immune cells in cancer

// Yinglong Zhang 1, * , Qiong Ma 1, * , Tao Liu 1, * , Guofeng Guan 2, * , Kailiang Zhang 3 , Jiayan Chen 4 , Nan Jia 1 , Shiju Yan 1 , Guanyin Chen 1 , Shiluan Liu 1 , Kuo Jiang 1 , Yao Lu 1 , Yanhua Wen 1 , Haien Zhao 1 , Yong Zhou 1 , Qingyu Fan 1 , Xiuchun Qiu 1 1 Orthopaedic Oncology Institute, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China 2 Department of Microsurgery, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China 3 Department of Orthopedics, No. 88 Hospital of PLA, Tai’an, Shandong, China 4 Department of Occupational and Environmental Health, School of Public Health, Fourth Military Medical University, Xi’an, Shaanxi, China * These authors have contributed equally to this work Correspondence to: Xiuchun Qiu, e-mail: xiuchun_qiu@yeah.net Qingyu Fan, e-mail: qingyu_fan@yeah.net Keywords: osteosarcoma, tumour self-seeding by circulating tumour cells, interleukin-6, metastasis, recurrence Received: June 15, 2015      Accepted: October 29, 2015      Published: November 09, 2015 ABSTRACT Tumour self-seeding by circulating tumour cells (CTCs) enhances tumour progression and recurrence. Previously, we demonstrated that tumour self-seeding by CTCs occurs in osteosarcoma and revealed that interleukin-6 (IL-6) may promote CTC attraction. Here, we investigated the underlying mechanisms of IL-6 in tumour self-seeding by CTCs. IL-6 suppression inhibited in v...