Nucleosome mobilization and positioning by ISWI-containing chromatin-remodeling factors

作者：Gernot Längst, Peter B. Becker · 发表于：Journal of Cell Science · 年份：2001 · DOI：10.1242/jcs.114.14.2561 · 被引用次数：202 · 研究领域：Chromatin Remodeling and Cancer、Cancer Mechanisms and Therapy、Genomics and Chromatin Dynamics

ATP-dependent chromatin-remodeling machines of the SWI/SNF family are involved in many cellular processes in eukaryotic nuclei, such as transcription, replication, repair and recombination. Remodeling factors driven by the ATPase ISWI make up a subgroup of this family that exhibits defined mechanistic and functional characteristics. ISWI-induced nucleosome mobility endows nucleosomal arrays with dynamic properties and recent results suggest that ISWI-type remodelers have diverse functions that range from transcriptional regulation to chromatin assembly and maintenance of chromosome structure.