Antibiotic Therapy for Chronic Infection of Pseudomonas in the Lung

作者：Niels Høiby · 发表于：Annual Review of Medicine · 年份：1993 · DOI：10.1146/annurev.me.44.020193.000245 · 被引用次数：80 · 研究领域：Cystic Fibrosis Research Advances、Inhalation and Respiratory Drug Delivery、Respiratory and Cough-Related Research

Chronic Pseudomonas aeruginosa lung infection is an endobronchiolitis characterized by the microcolony mode of growth (biofilm). Early colonization is treated with oral ciprofloxacin combined with colistin inhalation. Chronic infection is treated with "maintenance chemotherapy" consisting of beta-lactam antibiotics and tobramycin intravenously in combination with colistin inhalation four times yearly.