Results of radical surgery in women with stage IB2/IIA2 cervical cancer

作者：Marloes Derks, Petra Biewenga, Jacobus van der Velden, Gemma G. Kenter, Lukas J.A. Stalpers, Marrije R. Buist · 发表于：Acta Obstetricia Et Gynecologica Scandinavica · 年份：2015 · DOI：10.1111/aogs.12819 · 被引用次数：11 · 研究领域：Endometrial and Cervical Cancer Treatments、Cervical Cancer and HPV Research、Colorectal and Anal Carcinomas

INTRODUCTION: There is ongoing discussion about the primary treatment of women with bulky early-stage cervical cancer. Because of the high number of patients who need adjuvant (chemo)radiotherapy after initial surgical treatment, some state that primary (chemo)radiotherapy should be the treatment of choice to prevent morbidity. The aim of our study is to assess the results of radical surgery for women with bulky early-stage cervical cancer in terms of recurrence patterns and survival. MATERIALS AND METHODS: We conducted a retrospective cohort study. We included 129 women who underwent a radical hysterectomy with pelvic lymphadenectomy for stage IB2/IIA2 cervical cancer between 1984 and June 2010. Disease-specific survival was measured using a Kaplan-Meier method and univariate and multivariate regression analyses were performed to determine prognostic factors associated with survival. A literature search was performed to analyze our data in the context of findings from the literature. RESULTS: Five-year disease-specific survival was 84%. Fifty percent of the women received adjuvant treatment. The pelvic recurrence rate was 8%. With our multivariate analysis we found that histology, tumor diameter, and parametrial involvement were independently associated with disease-specific survival. Our literature search showed wide diversity in rates of adjuvant treatment after initial surgery as well as for survival and recurrence rates. CONCLUSIONS: In the context of current knowledge a...