5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

作者：Denise Corti, Paolo Paoli, Maura Calvani, Maria Letizia Taddei, Elisa Giannoni, Scott Kopetz, Syed Mohammad Ali Kazmi, Morelli Maria Pia, Piergiorgio Pettazzoni, Elena Sacco, Anna Caselli, Marco Vanoni, Matteo Landriscina, Paolo Cirri, Paola Chiarugi · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.5991 · 被引用次数：166 · 研究领域：Cancer, Hypoxia, and Metabolism、Cancer Cells and Metastasis、Cancer-related Molecular Pathways

// Corti Denise 1, 2, * , Paolo Paoli 1, * , Maura Calvani 1 , Maria Letizia Taddei 1 , Elisa Giannoni 1 , Scott Kopetz 2 , Syed Mohammad Ali Kazmi 2 , Morelli Maria Pia 2 , Piergiorgio Pettazzoni 2 , Elena Sacco 3 , Anna Caselli 1 , Marco Vanoni 3 , Matteo Landriscina 4 , Paolo Cirri 1 , Paola Chiarugi 1 1 Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy 2 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 3 SYSBIO Centre for Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy 4 Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy * These authors have contributed equally to this work Correspondence to: Paola Chiarugi, e-mail: paola.chiarugi@unifi.it Keywords: cancer metabolism, OXPHOS, chemoresistance, metformin, cancer stem cells Received: July 15, 2015 Accepted: October 09, 2015 Published: October 21, 2015 ABSTRACT Despite marked tumor shrinkage after 5-FU treatment, the frequency of colon cancer relapse indicates that a fraction of tumor cells survives treatment causing tumor recurrence. The majority of cancer cells divert metabolites into anabolic pathways through Warburg behavior giving an advantage in terms of tumor growth. Here, we report that treatment of colon cancer cell with 5-FU selects for cells with mesenchymal stem-like properties that undergo a metabolic...