Monoclonal Antibodies in Cancer Detection and Therapy

作者：Stephen J. Kennel, Kathy Flynn, Linda J. Foote, Trish K. Lankford · 发表于：BioScience · 年份：1984 · DOI：10.2307/1309749 · 被引用次数：109 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Glycosylation and Glycoproteins Research、Advanced Biosensing Techniques and Applications

The advent of monoclonal antibodies has revolutionized our thinking about cancer therapy management. In this article, we attempt to review some of the applications of monoclonal antibodies in cancer research and to identify requirements for monoclonal antibody to be useful in cancer detection or therapy. Empirical tests of antibody circulation in vivo are necessary to establish specificity. (Accepted for publication 15 July 1983)