Metal–Organic Frameworks as Efficient Materials for Drug Delivery

作者：Patricia Horcajada, Christian Serre, María Vallet‐Regí, Muriel Sebban, Françis Taulelle, Gérard Férey · 发表于：Angewandte Chemie International Edition · 年份：2006 · DOI：10.1002/anie.200601878 · 被引用次数：2010 · 研究领域：Metal-Organic Frameworks: Synthesis and Applications、X-ray Diffraction in Crystallography、Crystallography and molecular interactions

Fill 'em up: The metal carboxylates MIL-100 and MIL-101 act as porous matrices (see picture; MIL=Materials of Institut Lavoisier) for drug-delivery systems using Ibuprofen as a model substrate. Very large amounts of the drug could be incorporated, up to an unprecedented capacity of 1.4 g of drug per gram of porous solid for MIL-101, and the total release of Ibuprofen was achieved under physiological conditions in 3 (MIL-100) and 6 days (MIL-101).