Carriage of Internationally Spread Clones ofStreptococcus pneumoniaewith Unusual Drug Resistance Patterns in Children Attending Day Care Centers in Lisbon, Portugal

作者：Raquel Sá‐Leão, Alexander Tomasz, Ilda Santos Sanches, António Brito‐Avô, Sigurdur E. Vilhelmsson, Karl Gustaf Kristinsson, Hermı́nia de Lencastre · 发表于：The Journal of Infectious Diseases · 年份：2000 · DOI：10.1086/315813 · 被引用次数：90 · 研究领域：Pneumonia and Respiratory Infections、Pneumocystis jirovecii pneumonia detection and treatment、Respiratory viral infections research

Over half (259/503) of drug-resistant (DR) pneumococci colonizing healthy children attending day care centers in Lisbon were identified by molecular typing methods as representatives of several internationally spread clones. These included the 2 penicillin-resistant pandemic Spanish/USA and French/Spanish clones (21% of all DR pneumococci) and 5 new lineages with unusual antibiotypes (accounting for an additional 30% of all DR pneumococci). The most characteristic feature of the latter group was the high frequency of resistance to macrolides and tetracycline and very low or no resistance to penicillin. These observations provide support for the notion that the nasopharyngeal flora of children in day care centers may be a global reservoir of worldwide prevalent strains of DR pneumococci.