Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN

作者：Myrto Raftopoulou, Sandrine Etienne‐Manneville, Annette J. Self, Sarah Nicholls, Alan Hall · 发表于：Science · 年份：2004 · DOI：10.1126/science.1092089 · 被引用次数：353 · 研究领域：PI3K/AKT/mTOR signaling in cancer、Protein Kinase Regulation and GTPase Signaling、Polyamine Metabolism and Applications

PTEN is a tumor suppressor protein that dephosphorylates phosphatidylinositol 3,4,5 trisphosphate and antagonizes the phosphatidylinositol-3 kinase signaling pathway. We show here that PTEN can also inhibit cell migration through its C2 domain, independent of its lipid phosphatase activity. This activity depends on the protein phosphatase activity of PTEN and on dephosphorylation at a single residue, threonine(383). The ability of PTEN to control cell migration through its C2 domain is likely to be an important feature of its tumor suppressor activity.