CAMPTOTHECIN ANALOGUES/CISPLASTIN: AN EFFECTIVE TREATMENT OF ADVANCED BLADDER CANCER IN A PRECLINICAL IN VIVO MODEL SYSTEM

作者：Thomas E. Keane, Rizk El-Galley, Carrie Qi Sun, John A. Petros, Dirk Dillahey, A. H. Gomaa, SAM D. JR GRAHAM, William Patrick McGuire · 发表于：The Journal of Urology · 年份：1998 · DOI：10.1016/s0022-5347(01)63099-4 · 被引用次数：15 · 研究领域：Cancer therapeutics and mechanisms、Lung Cancer Research Studies、Synthesis and Biological Activity

OBJECTIVE: To evaluate the impact of the camptothecin analogs on human TCC xenograft, both as monotherapy and in combination with cisplatin (CDDP). MATERIALS AND METHODS: Human transitional cell carcinoma (TCC) xenograft tumor line (DU4184) tested by subrenal capsule assay in 112 nude mice(NM-SRCA). CDDP and the camptothecin analogs irinotecan (CPT-11) and 9-aminocamptothecin(9-AC) were evaluated. RESULTS: Both of the camptothecin analogs showed significant short term tumor inhibition which translated into enhanced survival. Maximal tumor inhibition (>95%) was achieved when either of the camptothecin analogs was combined with CDDP with minimal host toxicity. This translated into 400% increase in median survival. While all controls were dead 39 days following tumor implantation, none of the combination treated animals had died. CONCLUSION: The combination of CDDP with these camptothecin analogs is an effective therapy against this model of advanced TCC. These observations suggest potential clinical value.