Immunohistochemical localisation of thrombospondin in human megakaryocytes and platelets.

作者：Kathryn M. McLaren · 发表于：Journal of Clinical Pathology · 年份：1983 · DOI：10.1136/jcp.36.2.197 · 被引用次数：53 · 研究领域：Angiogenesis and VEGF in Cancer、Protease and Inhibitor Mechanisms、Hemostasis and retained surgical items

Thrombospondin (TSP) is a glycoprotein released from platelets after thrombin-induced aggregation. Endothelial culture studies suggest that it or a similar protein may also be produced by endothelial cells. The origin of the glycoprotein is therefore of some importance. This report concerns the immunohistochemical localisation of TSP within megakaryocytes and platelets. TSP would appear to be a primary platelet protein of megakaryocyte origin, rather than a substance taken up by the platelet in the circulation. The relation of this molecule to the endothelial glycoprotein remains to be established, but our preliminary immunohistochemical studies suggest that the molecule is also located in vascular endothelium.