Fatigue in Chronic Dialysis Patients

作者：Maurizio Bossola, Carlo Vulpio, Luigi Tazza · 发表于：Seminars in Dialysis · 年份：2011 · DOI：10.1111/j.1525-139x.2011.00956.x · 被引用次数：105 · 研究领域：Dialysis and Renal Disease Management、Muscle and Compartmental Disorders、Pharmacological Effects and Toxicity Studies

Fatigue is common in chronic hemodialysis (HD) patients and impacts on daily living, impairs significantly the quality of life, increases the risk of cardiovascular events and negatively influences survival. Although numerous social, demographic, clinical, and laboratory variables have been associated with fatigue, the causes of this symptom are often unclear. In the absence of an underlying, treatable disorder, the results of therapeutic intervention are typically frustrating. So far, none of the drugs tested can be recommended for preventing and treating fatigue in chronic HD patients. There is some evidence that exercise may significantly improve fatigue in dialysis patients; however, this requires confirmation through large, prospective, randomized studies.