RNAi in C. elegans : Soaking in the Genome Sequence

作者：Hiroaki Tabara, Alla Grishok, Craig C. Mello · 发表于：Science · 年份：1998 · DOI：10.1126/science.282.5388.430 · 被引用次数：644 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、CRISPR and Genetic Engineering、Pluripotent Stem Cells Research

T he completion of the Caenorhabditis elegans genome sequence represents a major milestone in a journey initiated by Sydney Brenner some 30 years ago. The goal then as now was to discover how genetic information specifies the development, anatomy, and behavior of a simple animal. Bringing the full