Functional Consequences of Integrin Gene Mutations in Mice

作者：Daniel Bouvard, Cord Herbert Brakebusch, Erika Gustafsson, Attila Aszódi, Therése Bengtsson, Alejandro Berna‐Erro, Reinhard Fässler · 发表于：Circulation Research · 年份：2001 · DOI：10.1161/hh1501.094874 · 被引用次数：264 · 研究领域：Cell Adhesion Molecules Research、Cellular Mechanics and Interactions、RNA Interference and Gene Delivery

Integrins are cell-surface receptors responsible for cell attachment to extracellular matrices and to other cells. The application of mouse genetics has significantly increased our understanding of integrin function in vivo. In this review, we summarize the phenotypes of mice carrying mutant integrin genes and compare them with phenotypes of mice lacking the integrin ligands.