Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging

作者：Lei Jing, Qian Han, Shaocheng Zhu, Dapeng Shi, Shewei Dou, Zihua Su, Xiao‐Quan Xu · 发表于：Oncology Letters · 年份：2015 · DOI：10.3892/ol.2015.3779 · 被引用次数：34 · 研究领域：Esophageal Cancer Research and Treatment、MRI in cancer diagnosis、Gastric Cancer Management and Outcomes

The aim of the present study was to investigate whether quantitative dynamic contrast‑enhanced magnetic resonance imaging (DCE-MRI) can predict an early response in primary esophageal carcinoma patients undergoing concurrent chemoradiotherapy. A total of 25 patients with who were pathologically confirmed stage II-III esophageal carcinoma underwent quantitative DCE-MRI prior to chemoradiotherapy, and at 3 weeks post-treatment, the quantitative parameters [Ktrans (volume transfer constant; the rate at which contrast agent distributes from the plasma to the EES), Kep (rate contrast; the rate at which the contrast agent that has diffused to the EES returns to the plasma) and Ve (the contrast agent percentage in the space of the extracellular fluid)] were analyzed respectively. The 25 cases were categorized as a complete response (CR) or a partial response (PR). An independent samples Mann‑Whitney U test was used to compare the quantitative parameters between CR and PR. A receiver operating characteristic curve (ROC) was used to determine the best predictor. In total, 17 patients were in the CR group and 8 patients were in the PR group. Pretreatment Ktrans, Kep and Ve values were 0.54±0.17/min, 1.12±0.46/min and 0.37±0.14, respectively, in the CR group, and 0.40±0.21/min, 1.07±0.37/min and 0.40±0.22, respectively, in the PR group. There was a significant difference between the two groups for Ktrans, but there were no significant differences between the two groups for Kep and Ve. T...