The scanning model for translation: an update.

作者：Marilyn Kozak · 发表于：The Journal of Cell Biology · 年份：1989 · DOI：10.1083/jcb.108.2.229 · 被引用次数：3546 · 研究领域：RNA and protein synthesis mechanisms、RNA Research and Splicing、Viral Infections and Immunology Research

The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained.