Preservation of Fertility in Pediatric and Adolescent Patients With Cancer

作者：Mary Elizabeth Fallat, John Hutter · 发表于：PEDIATRICS · 年份：2008 · DOI：10.1542/peds.2008-0593 · 被引用次数：244 · 研究领域：Reproductive Biology and Fertility、Reproductive Health and Technologies、Assisted Reproductive Technology and Twin Pregnancy

Many cancers that present in children and adolescents are curable with surgery, chemotherapy, and/or radiation therapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of either gonad removal or damage to germ cells from adjuvant therapy. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonads. Simultaneously, advances in assisted reproductive techniques have led to new possibilities for the prevention and treatment of infertility. This technical report reviews the topic of fertility preservation in pediatric and adolescent patients with cancer, including ethical considerations.