A Meta-Analysis of Cognitive Remediation in Schizophrenia

作者：Susan R. McGurk, Elizabeth W. Twamley, David Sitzer, Gregory J. McHugo, Kim T. Mueser · 发表于：American Journal of Psychiatry · 年份：2007 · DOI：10.1176/appi.ajp.2007.07060906 · 被引用次数：1213 · 研究领域：Schizophrenia research and treatment、Healthcare Decision-Making and Restraints、Mental Health and Psychiatry

OBJECTIVE: This study evaluated the effects of cognitive remediation for improving cognitive performance, symptoms, and psychosocial functioning in schizophrenia. METHOD: A meta-analysis was conducted of 26 randomized, controlled trials of cognitive remediation in schizophrenia including 1,151 patients. RESULTS: Cognitive remediation was associated with significant improvements across all three outcomes, with a medium effect size for cognitive performance (0.41), a slightly lower effect size for psychosocial functioning (0.36), and a small effect size for symptoms (0.28). The effects of cognitive remediation on psychosocial functioning were significantly stronger in studies that provided adjunctive psychiatric rehabilitation than in those that provided cognitive remediation alone. CONCLUSIONS: Cognitive remediation produces moderate improvements in cognitive performance and, when combined with psychiatric rehabilitation, also improves functional outcomes.