Silver‐Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3‐Trifluoromethylpyrazoles

作者：Feng Li, Jing Nie, Long Sun, Yan Zheng, Jun‐An Ma · 发表于：Angewandte Chemie International Edition · 年份：2013 · DOI：10.1002/anie.201301870 · 被引用次数：187 · 研究领域：Fluorine in Organic Chemistry、Cyclopropane Reaction Mechanisms、Synthesis and Biological Evaluation

Silver screen: The title reaction provides a convenient and efficient method for the construction of 5-substituted 3-trifluoromethylpyrazoles under mild reaction conditions. By using this protocol, the marketed drug Celecoxib (antiarthritic) could be easily synthesized (see scheme; DMF=N,N-dimethylformamide).