Kinesin Superfamily Motor Protein KIF17 and mLin-10 in NMDA Receptor-Containing Vesicle Transport

作者：Mitsutoshi Setou, Terunaga Nakagawa, Dae‐Hyun Seog, Nobutaka Hirokawa · 发表于：Science · 年份：2000 · DOI：10.1126/science.288.5472.1796 · 被引用次数：714 · 研究领域：Microtubule and mitosis dynamics、Cellular transport and secretion、Hippo pathway signaling and YAP/TAZ

Experiments with vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites. Selective transport is accomplished by direct interaction of the KIF17 tail with a PDZ domain of mLin-10 (Mint1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/Velis), and the NR2B subunit. This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis.