Subcortical Alterations in Tissue Microstructure Adjacent to Focal Cortical Dysplasia: Detection at Diffusion-Tensor MR Imaging by Using Magnetoencephalographic Dipole Cluster Localization

作者：Elysa Widjaja, Sina Zarei Mahmoodabadi, Hiroshi Otsubo, O. Carter Snead, Stephanie Holowka, Sonya Bells, Charles Raybaud · 发表于：Radiology · 年份：2009 · DOI：10.1148/radiol.2511081092 · 被引用次数：82 · 研究领域：Epilepsy research and treatment、Advanced Neuroimaging Techniques and Applications、Functional Brain Connectivity Studies

PURPOSE: To determine whether changes at diffusion-tensor magnetic resonance (MR) imaging were present in children with intractable epilepsy and focal cortical dysplasia (FCD) in (a) subcortical white matter subjacent to MR imaging-visible areas of FCD, (b) subcortical white matter beyond the MR imaging-visible abnormality but subjacent to a magnetoencephalographic (MEG) dipole cluster, and (c) deep white matter tracts. MATERIALS AND METHODS: The study protocol had institutional research ethics board approval, and written informed consent was obtained. Fifteen children with FCD and intractable epilepsy (mean age, 11.6 years; range, 3.6-18.3 years) underwent diffusion-tensor MR imaging and MEG. Regions of interest were placed in (a) the subcortical white matter subjacent to the MR imaging-visible abnormality, as well as the contralateral side; (b) the subcortical white matter beyond the MR imaging-visible abnormality but subjacent to a MEG dipole cluster, as well as the contralateral side; and (c) deep white matter tracts projecting to or from the MR imaging-visible FCD, as well as the contralateral side. Fractional anisotropy (FA), mean diffusivity, and eigenvalues (lambda(1), lambda(2), lambda(3)) were evaluated. RESULTS: Eleven of 15 children had MEG dipole clusters, and four children had MEG scatter. There were significant differences in FA, mean diffusivity, lambda(2), and lambda(3) of the subcortical white matter subjacent to the MR imaging-visible FCD (P < .001 for all)...