Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii

作者：Jean Duplex Wansi, Hidayat Hussain, Alain Tadjong Tcho, Siméon F. Kouam, Sabine Specht, Salem Ramadan Sarite, Achim M. Hoerauf, Karsten Krohn · 发表于：Phytotherapy Research · 年份：2009 · DOI：10.1002/ptr.2894 · 被引用次数：39 · 研究领域：Bioactive Compounds and Antitumor Agents、Synthesis and Biological Evaluation、Plant chemical constituents analysis

The study of the chemical constituents of the stem bark of Teclea afzelii (Rutaceae) has resulted in the isolation and characterization of four furoquinoline alkaloids, namely kokusaginine (1), tecleaverdoornine (2), maculine (3) and montrifoline (4) together with lupeol (5) and beta-sitosterol glucopyranoside (6). The structures of the isolated compounds were elucidated based on spectroscopic studies. The antimalarial activity of compounds 1-4 against Plasmodium falciparum in vitro shows partial suppression of parasitic growth.