In vivo validation of a one-dimensional finite-element method for predicting blood flow in cardiovascular bypass grafts

作者：Brooke N. Steele, Jing Wan, Joy P. Ku, Thomas J.R. Hughes, Charles A. Taylor · 发表于：IEEE Transactions on Biomedical Engineering · 年份：2003 · DOI：10.1109/tbme.2003.812201 · 被引用次数：124 · 研究领域：Coronary Interventions and Diagnostics、Aortic aneurysm repair treatments、Cardiac and Coronary Surgery Techniques

Current practice in vascular surgery utilizes only diagnostic and empirical data to plan treatments and does not enable quantitative a priori prediction of the outcomes of interventions. We have previously described a new approach to vascular surgery planning based on solving the governing equations of blood flow in patient-specific models. A one-dimensional finite-element method was used to simulate blood flow in eight porcine thoraco-thoraco aortic bypass models. The predicted flow rate was compared to in vivo data obtained using cine phase-contrast magnet resonance imaging. The mean absolute difference between computed and measured flow distribution in the stenosed aorta was found to be 4.2% with the maximum difference of 10.6% anda minimum difference of 0.4%. Furthermore, the sensitivity of the flow rate and distribution with respect to stenosis and branch losses were quantified.