Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli

作者：Keiji Hirai, Hiroshi Aoyama, Tsutomu Irikura, Shizuko Iyobe, S Mitsuhashi · 发表于：Antimicrobial Agents and Chemotherapy · 年份：1986 · DOI：10.1128/aac.29.3.535 · 被引用次数：256 · 研究领域：Antibiotic Resistance in Bacteria、Lipid Membrane Structure and Behavior、Antibiotics Pharmacokinetics and Efficacy

The mechanism of penetration of quinolones through the bacterial outer membrane was studied with lipopolysaccharide-deficient and porin-deficient mutants. The data indicated that the lipopolysaccharide layer might form a permeability barrier for hydrophobic quinolones such as nalidixic acid but not for hydrophilic quinolones such as norfloxacin and ciprofloxacin. The results also showed that quinolones with a low relative hydrophobicity appeared to permeate through OmpF porin, whereas quinolones with a low relative hydrophobicity appeared to permeate through OmpF porin, whereas quinolones with a high relative hydrophobicity appeared to permeate through both OmpF porin and phospholipid bilayers.