Bacterial Programmed Cell Death and Multicellular Behavior in Bacteria

作者：Hanna Engelberg–Kulka, Shahar Amitai, Ilana Kolodkin‐Gal, Ronen Hazan · 发表于：PLoS Genetics · 年份：2006 · DOI：10.1371/journal.pgen.0020135 · 被引用次数：433 · 研究领域：Vibrio bacteria research studies、Bacterial Genetics and Biotechnology、Bacterial biofilms and quorum sensing

Traditionally, programmed cell death (PCD) is associated with eukaryotic multicellular organisms. However, recently, PCD systems have also been observed in bacteria. Here we review recent research on two kinds of genetic programs that promote bacterial cell death. The first is mediated by mazEF, a toxin-antitoxin module found in the chromosomes of many kinds of bacteria, and mainly studied in Escherichia coli. The second program is found in Bacillus subtilis, in which the skf and sdp operons mediate the death of a subpopulation of sporulating bacterial cells. We relate these two bacterial PCD systems to the ways in which bacterial populations resemble multicellular organisms.