Simultaneous sensitivity to fragrances

作者：Deirdre Anne Buckley, David Arthur Basketter, Camilla K. Smith Pease, Richard J. G. Rycroft, Ian R. White, John Paul McFadden · 发表于：British Journal of Dermatology · 年份：2006 · DOI：10.1111/j.1365-2133.2006.07170.x · 被引用次数：25 · 研究领域：Contact Dermatitis and Allergies、Allergic Rhinitis and Sensitization、Advanced Chemical Sensor Technologies

BACKGROUND: Cinnamal/cinnamic alcohol and isoeugenol/eugenol are pairs of related fragrance chemicals found in Fragrance Mix I (FM I), and thus are routinely tested in combination with other fragrances in the European standard patch test series. Their close structural similarity makes the occurrence of simultaneous sensitivity within these chemical pairs likely, although at present there are no robust data to support this hypothesis. OBJECTIVES: To establish the frequency of simultaneous reactions to these fragrance chemicals in patients with suspected fragrance allergy attending a contact dermatitis clinic; to provide evidence in support of proposed metabolic pathways; and to determine whether including all four separately in FM I is necessary to avoid missing a diagnosis of fragrance allergy. METHODS: We analysed retrospectively the records of patients patch tested to the European standard series during the 15-year period 1984-98 for positive reactions to FM I. In a subset of patients tested to the constituents of FM I, positive reactions to cinnamal, cinnamic alcohol, isoeugenol and eugenol were sought. Data were analysed using 2x2 contingency tables (Fisher's exact test). RESULTS: During this period, 23,660 patients were tested to the European standard series, of whom 1811 (7.7%) had positive reactions to FM I. Of the 1112 patients tested to the constituents of FM I, 934 had positive reactions to at least one constituent (total 1324 positive reactions to constituents). Of...