Endometrial progesterone resistance and PCOS

作者：Xin Li, Yi Feng, Lin Jin-fang, Håkan Billig, Ruijin Shao · 发表于：Journal of Biomedical Science · 年份：2014 · DOI：10.1186/1423-0127-21-2 · 被引用次数：158 · 研究领域：Ovarian function and disorders、Endometriosis Research and Treatment、Reproductive System and Pregnancy

Polycystic ovary syndrome (PCOS) is a state of altered steroid hormone production and activity. Chronic estrogen exposure or lack of progesterone due to ovarian dysfunction can result in endometrial hyperplasia and carcinoma. A key contributor to our understanding of progesterone as a critical regulator for normal uterine function has been the elucidation of progesterone receptor (PR) expression, regulation, and signaling pathways. Several human studies indicate that PR-mediated signaling pathways in the nucleus are associated with progesterone resistance in women with PCOS. The aim of this review is to provide an overview of endometrial progesterone resistance in women with PCOS; to present the PR structure, its different isoforms, and their expression in the endometrium; to illustrate the possible regulation of PR and PR-mediated signaling in progesterone resistance in women with PCOS; and to discuss current clinical treatments for atypical endometrial hyperplasia and endometrial carcinoma in women with PCOS and accompanying progesterone resistance.