Preventable Exposures Associated With Human Cancers

作者：Vincent James Cogliano, Robert A. Baan, Kurt Straíf, Y. Grosse, Béatrice Secretan, Fatiha El Ghissassi, Véronique Bouvard, Lamia Benbrahim‐Tallaa, Neela Guha, Crystal Freeman, Laurent Galichet, Christopher Paul Wild · 发表于：JNCI Journal of the National Cancer Institute · 年份：2011 · DOI：10.1093/jnci/djr483 · 被引用次数：834 · 研究领域：Global Cancer Incidence and Screening、Carcinogens and Genotoxicity Assessment、Colorectal Cancer Screening and Detection

Information on the causes of cancer at specific sites is important to cancer control planners, cancer researchers, cancer patients, and the general public. The International Agency for Research on Cancer (IARC) Monograph series, which has classified human carcinogens for more than 40 years, recently completed a review to provide up-to-date information on the cancer sites associated with more than 100 carcinogenic agents. Based on IARC's review, we listed the cancer sites associated with each agent and then rearranged this information to list the known and suspected causes of cancer at each site. We also summarized the rationale for classifications that were based on mechanistic data. This information, based on the forthcoming IARC Monographs Volume 100, offers insights into the current state-of-the-science of carcinogen identification. Use of mechanistic data to identify carcinogens is increasing, and epidemiological research is identifying additional carcinogens and cancer sites or confirming carcinogenic potential under conditions of lower exposure. Nevertheless, some common human cancers still have few (or no) identified causal agents.