Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles

作者：Debbie L. Hay, Augen A. Pioszak · 发表于：The Annual Review of Pharmacology and Toxicology · 年份：2015 · DOI：10.1146/annurev-pharmtox-010715-103120 · 被引用次数：192 · 研究领域：Neuropeptides and Animal Physiology、Receptor Mechanisms and Signaling、Chemical Synthesis and Analysis

It is now recognized that G protein-coupled receptors (GPCRs), once considered largely independent functional units, have a far more diverse molecular architecture.Receptor activity-modifying proteins (RAMPs) provide an important example of proteins that interact with GPCRs to modify their function.RAMPs are able to act as pharmacological switches and chaperones, and they can regulate signaling and/or trafficking in a receptor-dependent manner.This review covers recent discoveries in the RAMP field and summarizes the known GPCR partners and functions of RAMPs.We also discuss the first peptide-bound structures of RAMP-GPCR complexes, which give insight into the molecular mechanisms that enable RAMPs to alter the pharmacology and signaling of GPCRs.469 Click here to view this article's online features: • Download figures as PPT slides • Navigate linked references • Download citations • Explore related articles • Search