Bio-functionalization of metal–organic frameworks by covalent protein conjugation

作者：Suhyun Jung, Youngmee Kim, Sung‐Jin Kim, Tae‐Hwan Kwon, Seong Huh, Seongsoon Park · 发表于：Chemical Communications · 年份：2011 · DOI：10.1039/c0cc03288c · 被引用次数：251 · 研究领域：Metal-Organic Frameworks: Synthesis and Applications、Covalent Organic Framework Applications、Dendrimers and Hyperbranched Polymers

Bioconjugation of functional proteins onto metal-organic frameworks (MOFs) has been achieved using activation of pendent linking groups of the organic linkers on the surface of MOFs. Fluorescent microscopy revealed successful conjugation of an enhanced fluorescent protein onto MOFs. In addition, Candida-antarctica-lipase-B-conjugated MOFs showed no loss of enantioselectivity and activity in transesterification of (±)-1-phenylethanol.