IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex

作者：Alissa A. Chackerian, Elizabeth R. Oldham, Erin E. Murphy, Jochen Schmitz, Stefan Pflanz, Robert A. Kastelein · 发表于：The Journal of Immunology · 年份：2007 · DOI：10.4049/jimmunol.179.4.2551 · 被引用次数：515 · 研究领域：IL-33, ST2, and ILC Pathways、Eosinophilic Esophagitis

IL-33 (IL-1F11) is a recently described member of the IL-1 family of cytokines that stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune response. IL-33 mediates signal transduction through ST2, a receptor expressed on Th2 and mast cells. In this study, we demonstrate that IL-33 and ST2 form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex. Additionally, IL-1RAcP is required for IL-33-induced in vivo effects, and IL-33-mediated signal transduction can be inhibited by dominant-negative IL-1RAcP. The implications of this shared usage of IL-1RAcP by IL-1(alpha and beta) and IL-33 are discussed.