Genome Sequence of the Plant Pathogen and Biotechnology Agent Agrobacterium tumefaciens C58

作者：Brad W. Goodner, Gregory Hinkle, Stacie Gattung, Nancy Miller, Mary Blanchard, Barbara A. Qurollo, Barry S. Goldman, Yongwei Cao, Manor Askenazi, Conrad Halling, Lori Mullin, Kathryn L. Houmiel, Jeffrey Gordon, Mark D. Vaudin, Oleg Iartchouk, Andrew Epp, Fang Liu, Clifford Wollam, Mike Allinger, Dahlia Doughty, Charlaine Scott, Courtney M. Lappas, Brian Markelz, Casey M Flanagan, Chris B. Crowell, Jordan Gurson, Caroline Lomo, Carolyn Sear, Graham M. Strub, Chris Cielo, Steven C. Slater · 发表于：Science · 年份：2001 · DOI：10.1126/science.1066803 · 被引用次数：653 · 研究领域：Plant Pathogenic Bacteria Studies、Genomics and Phylogenetic Studies、Plant tissue culture and regeneration

Agrobacterium tumefaciens is a plant pathogen capable of transferring a defined segment of DNA to a host plant, generating a gall tumor. Replacing the transferred tumor-inducing genes with exogenous DNA allows the introduction of any desired gene into the plant. Thus, A. tumefaciens has been critical for the development of modern plant genetics and agricultural biotechnology. Here we describe the genome of A. tumefaciens strain C58, which has an unusual structure consisting of one circular and one linear chromosome. We discuss genome architecture and evolution and additional genes potentially involved in virulence and metabolic parasitism of host plants.