KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer

作者：Goutham Narla, Karen E. Heath, Helen L. Reeves, Dan Li, Luciana E. Giono, Alec C. Kimmelman, Marc Glucksman, Jyothsna Narla, Francis J. Eng, Andrew M. Chan, Anna C. Ferrari, John A. Martignetti, Scott L. Friedman · 发表于：Science · 年份：2001 · DOI：10.1126/science.1066326 · 被引用次数：453 · 研究领域：Kruppel-like factors research、Cancer-related gene regulation、Epigenetics and DNA Methylation

Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6 allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer.