Serum Total IGF-I, Free IGF-I, and IGFBP-1 Levels in an Elderly Population

作者：J. A. M. J. L. Janssen, Ronald P. Stolk, H.A.P. Pols, Diederik E. Grobbee, Steven W. J. Lamberts · 发表于：Arteriosclerosis Thrombosis and Vascular Biology · 年份：1998 · DOI：10.1161/01.atv.18.2.277 · 被引用次数：243 · 研究领域：Growth Hormone and Insulin-like Growth Factors、Pituitary Gland Disorders and Treatments、Metabolism, Diabetes, and Cancer

Recently, a method to measure free insulin-like growth factor-I (IGF-I) levels has been developed. Free IGF-I levels may have greater physiological and clinical relevance than total (bound and free) IGF-I. The associations between the circulating IGF-I/IGF binding protein (IGFBP) system and cardiovascular disorders was studied. In a cross-sectional study of 218 healthy persons (103 men, 115 women) aged 55 to 80 years, fasting serum (total and free) IGF-I and IGFBP-1 levels, lipid profile, insulin, and glucose were measured. In addition, blood pressure, body mass index (BMI), and waist-hip ratio (WHR) were measured. Ultrasonography of both carotid arteries was performed to investigate the presence of atherosclerotic lesions. A history of angina pectoris, the presence of a possible or definite myocardial infarction on the ECG, and plaques in the carotid arteries were used as indicators of presence of cardiovascular signs and symptoms. Free IGF-I was inversely related to serum triglycerides (P=.04, adjusted for age and sex). Mean free IGF-I levels in subjects without signs or symptoms of cardiovascular diseases were significantly higher than in those with at least one cardiovascular symptom or sign (P=.002, adjusted for age and sex). Free IGF-I levels were also higher in subjects who had no atherosclerotic plaques in the carotid arteries (P=.02, adjusted for age and sex) and who had never smoked (P=.02, adjusted for age and sex). IGFBP-1 showed an inverse relation with insulin, ...