Greatly Improved Blood Compatibility by Microscopic Multiscale Design of Surface Architectures

作者：Honglei Fan, Peipei Chen, Ruomei Qi, Jin Zhai, Jingxia Wang, Chen Long, Li Chen, Quanmei Sun, Yanlin Song, Dong Han, Lei Jiang · 发表于：Small · 年份：2009 · DOI：10.1002/smll.200900345 · 被引用次数：86 · 研究领域：Polymer Surface Interaction Studies、Nanofabrication and Lithography Techniques、Block Copolymer Self-Assembly

A multiscale architecture with interlaced submicrometer ridges and nanoprotrusions is built on a polydimethylsiloxane (PDMS) surface by a combination of self-assembly, soft lithography, and physical treatment (see picture). The multiscale structure reduces activated-platelet adhesion under flow conditions, which is significant for the development of blood-contacting materials.