The Effect of Hypoxia on Mesenchymal Stem Cell Biology

作者：Mostafa Ejtehadifar, Karim Shamsasenjan, Ali Akbar Movassaghpour, Parvin Akbarzadehlaleh, Nima Dehdilani, Parvaneh Abbasi, Zahra Molaeipour, Mahshid Saleh · 发表于：Advanced Pharmaceutical Bulletin · 年份：2015 · DOI：10.15171/apb.2015.021 · 被引用次数：248 · 研究领域：Mesenchymal stem cell research、Cancer, Hypoxia, and Metabolism、Adipose Tissue and Metabolism

Although physiological and pathological role of hypoxia have been appreciated in mammalians for decades however the cellular biology of hypoxia more clarified in the past 20 years. Discovery of the transcription factor hypoxia-inducible factor (HIF)-1, in the 1990s opened a new window to investigate the mechanisms behind hypoxia. In different cellular contexts HIF-1 activation show variable results by impacting various aspects of cell biology such as cell cycle, apoptosis, differentiation and etc. Mesenchymal stem cells (MSC) are unique cells which take important role in tissue regeneration. They are characterized by self-renewal capacity, multilineage potential, and immunosuppressive property. Like so many kind of cells, hypoxia induces different responses in MSCs by HIF- 1 activation. The activation of this molecule changes the growth, multiplication, differentiation and gene expression profile of MSCs in their niche by a complex of signals. This article briefly discusses the most important effects of hypoxia in growth kinetics, signalling pathways, cytokine secretion profile and expression of chemokine receptors in different conditions.