Invasive Pneumococcal Disease in England and Wales: Vaccination Implications

作者：Karen L. Sleeman, Kyle Knox, Robert C. George, Elizabeth J. Miller, Pauline Waight, David Griffiths, Androulla Efstratiou, Karen Broughton, Richard T Mayon-White, E. Richard Moxon, Derrick W. Crook · 发表于：The Journal of Infectious Diseases · 年份：2001 · DOI：10.1086/317924 · 被引用次数：127 · 研究领域：Pneumonia and Respiratory Infections、Pneumocystis jirovecii pneumonia detection and treatment、Respiratory viral infections research

Knowledge of the epidemiology of invasive pneumococcal disease (IPD) will aid in planning the use of pneumococcal vaccines. A United Kingdom (UK)-based surveillance in England and Wales (1995-1997) of 11,528 individuals with IPD and a local enhanced surveillance in the Oxford (UK) area (1995-1999) have been analyzed. IPD has a high attack rate in children, with 37.1-48.1 cases per 100,000 infants <1 year old per year, and in older persons, with 21.2-36.2 cases per 100,000 persons >65 years old per year, for England, Wales, and Oxford. The 7-valent conjugate vaccine includes serotypes causing < or =79% of IPD in children <5 years old, but only 66% in adults >65 years old. The data also indicate that IPD varies by serotype, age, and country, emphasizing that the epidemiology of IPD is heterogeneous and requires continued surveillance.