Association Between Major Depressive Disorder and Heart Rate Variability in the Netherlands Study of Depression and Anxiety (NESDA)

作者：Carmilla M.M. Licht, Eco J. C. de Geus, Frans G. Zitman, Witte J.G. Hoogendijk, Richard van Dyck, Brenda W.J.H. Penninx · 发表于：Archives of General Psychiatry · 年份：2008 · DOI：10.1001/archpsyc.65.12.1358 · 被引用次数：384 · 研究领域：Heart Rate Variability and Autonomic Control、Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes、Cardiac Health and Mental Health

CONTEXT: It has been hypothesized that depression is associated with lower heart rate variability and decreased cardiac vagal control. This may play an important role in the risk of cardiovascular disease among depressed individuals. OBJECTIVE: To determine whether heart rate variability was lower in depressed individuals than in healthy controls in a large adult sample. DESIGN: Cross-sectional analyses from a large depression cohort study. SETTING: The Netherlands Study of Depression and Anxiety. PARTICIPANTS: Two thousand three hundred seventy-three individuals (mean age, 41.8 years; 66.8% female) who participated in the Netherlands Study of Depression and Anxiety. Included were 524 controls, 774 individuals with a diagnosis of major depressive disorder (MDD) earlier in life (remitted MDD), and 1075 individuals with current MDD based on the Composite International Diagnostic Interview. This sample was sufficiently powered to examine the confounding effects of lifestyle, comorbid anxiety, and antidepressants. MAIN OUTCOME MEASURES: The standard deviation of normal-to-normal beats (SDNN) and cardiac vagal control, as indexed by respiratory sinus arrhythmia (RSA), were measured during 1(1/2) hours of ambulatory recording of electrocardiograms and thorax impedance. Multivariate analyses were conducted to compare SDNN and RSA across depression groups after adjustment for demographics, health, lifestyle, comorbid anxiety, and psychoactive medication. RESULTS: Individuals with rem...