Enteric alpha defensins in norm and pathology

作者：Nikolai A. Lisitsyn, Yulia A. Bukurova, И. Г. Никитина, George Sergeevich Krasnov, Yuri K. Sykulev, Sergey F. Beresten · 发表于：Annals of Clinical Microbiology and Antimicrobials · 年份：2012 · DOI：10.1186/1476-0711-11-1 · 被引用次数：74 · 研究领域：Antimicrobial Peptides and Activities、Pediatric health and respiratory diseases、Infant Nutrition and Health

Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.