Activation and Cell Cycle Antigens in CD4+and CD8+T Cells Correlate with Plasma Human Immunodeficiency Virus (HIV‐1) RNA Level in HIV‐1 Infection

作者：Jurgen M. Orendi, Andries C. Bloem, Jan C.C. Borleffs, Folko‐Jan Wijnholds, N. Machiel de Vos, Hans S.L.M. Nottet, Maarten R. Visser, Harm Snippe, J. Verhoef, Charles A. Boucher · 发表于：The Journal of Infectious Diseases · 年份：1998 · DOI：10.1086/314451 · 被引用次数：121 · 研究领域：HIV Research and Treatment、Immune Cell Function and Interaction、Cytomegalovirus and herpesvirus research

The relationship between T cell activation and human immunodeficiency virus type 1 (HIV-1) replication was studied in HIV-infected subjects, 20 with and 10 without anti-HIV treatment. Expression of Ki-67 proliferation-associated antigen was increased in CD4+ and CD8+ T cells and correlated with HLA-DR. In subjects without anti-HIV treatment, the plasma HIV-1 RNA level correlated with HLA-DR in CD4+ T cells, with Ki-67 in CD8+ T cells, and with expression of CD38 in both T cell subsets. A proportion of treated subjects had increased T cell activation despite 4 months of highly active antiretroviral treatment (HAART). In subjects receiving HAART, a high percentage of HLA-DR+ CD4+ T cells was associated with signs of opportunistic infections. This work supports the concept that, in the natural course of HIV-1 infection, HIV replication itself leads to general T cell activation and that opportunistic infections generate additional CD4+ T cell activation and HIV replication.