Multifunctional BODIPY derivatives to image cancer cells and sense copper(ii) ions in living cells

作者：Zan Li, Qiu‐Yun Chen, Peidong Wang, Yi Wu · 发表于：RSC Advances · 年份：2013 · DOI：10.1039/c3ra22907f · 被引用次数：42 · 研究领域：Molecular Sensors and Ion Detection、Luminescence and Fluorescent Materials、Advanced biosensing and bioanalysis techniques

Two multifunctional colorimetric and fluorescent chemosensors were synthesized by the conjugation of BODIPY (4,4-difluoro-1, 3, 5, 7-tetramethyl-4-bora-3a, 4a-diaza-s-indacene) and di(2-picolyl)amine with benzyl groups (para-substituted, L1; meta-substituted, L2) as spacers, for selectively sensing copper(II) ions in preference to a variety of other common metal ions in aqueous media. The two analogous compounds exhibit different cytotoxic behaviour and attenuate mitochondrial membrane potentials in HepG-2 cells. In vitro bioassay results demonstrate that only L2 causes the decrease of mitochondrial membrane potentials in HepG-2 cells with low toxicity. Furthermore, fluorescence imaging in vitro confirms that L2 is a low toxicity chemosensor for copper(II) ions in living cells.